9α-OH-AD

1. Product introduction

　　9α-OH-AD is an important precursor for the production of corticosteroids with halogens at the 9α position, which plays a very important regulatory role in the body, and many steroidal hormone drugs are produced with 9α-oh-ad as the starting raw material; the use of 9α-oh-ad allows the synthesis of a wide range of important steroidal drugs such as hydrocortisone, 17α-hydroxyprogesterone, eplerenone, dexamethasone, betamethasone, cortisone, flunasalone acetate, fluohydroxyprednisolone and other important steroidal drugs of great commercial value.

2. Technology parameter

　　Biotransformation method to produce 9α-OH-AD from phytosterol.
　　Adding amount of phytosterol (25g/L): 2.5%; 
　　Final titre: 10g/L; 
　　Fermentation time: 120hrs