Histidine

1. Production introduction

　　Histidine is considered an essential amino acid for humans, primarily children. After many years of development, humans begin to be able to synthesize it themselves, at which point it becomes a non-essential amino acid. When small amounts of histidine are added to the diets of patients with chronic uremia, the rate of amino acid incorporation into hemoglobin is increased and nephrogenic anemia is reduced, so histidine is also an essential amino acid for uremic patients. Histidine is also one of the necessary raw materials for the synthesis of some pharmaceutical intermediates, such as the blue copper peptide ghk-cu. Histidine can reduce the acidity of gastric juice, ease the pain of gastrointestinal surgery, reduce vomiting and heartburn during pregnancy, inhibit the digestive tract ulcers caused by the vegetative nerve tension, and also has the effect on allergic diseases, such as asthma. In addition, histidine can dilate blood vessels, reduce blood pressure, clinically used in angina pectoris, cardiac insufficiency and other diseases. Rheumatoid arthritis patients have a significant reduction of histidine in the blood, and the use of histidine can improve their grip strength, walking and blood sedimentation and other indicators.

2. Technology parameter

　　Strain: Corynebacterium；
　　Fermentation titre: 30-35g/L; 
　　Fermentation time: 45hrs;
　　DSP yield: 55-60%